Perhaps the most promising approach to improving upon FFDM results is the combination of a DBT acquisition with a dual-energy technique to obtain time-resolved information on contrast-enhanced digital mammography (CEDM). CEDM increases the detection of low-contrast lesions in dense breast tissue by injecting a contrast agent (usually iodinated). The unique spectral capabilities of HPC detectors allow CEDM measurements to be performed in a single exposure — thereby limiting the patient’s radiation dose. These detectors isolate the K-edge of iodine for optimal contrast with fast acquisition. This helps avoid any motion artifacts introduced by contrast agent diffusion. Of all available technologies, HPC detectors alone fulfill all the requirements to perform this technique in a single-exposure mode.