How to build an electron diffractometer: new guidelines

Microcrystal electron diffraction (MicroED) has been in many crystallographers’ minds during the last few months, as experiments have shown that atomic resolution is within the reach of almost any transmission electron microscope (TEM). The technique has already helped researchers determine protein structures comparable to those discovered via X-ray crystallography. MicroED fills the gap between traditional X-ray crystallography and powder X-ray diffraction while making determination faster and easier, which means the technique will become very useful for structural chemistry and structure-based drug design.

Read this sponsored article in the International Union of Crystallography (IUCr) Newsletter to learn more about suggested design guidelines for a cost-effective electron diffractometer and to see examples of structures recently determined using MicroED.